Thermo Fisher Scientific MAVS Polyclonal Antibody, FITC
MAVS 단백질을 인식하는 FITC 결합 토끼 폴리클로날 항체로, 인간 시료에 반응합니다. Western blot, ELISA, IP 등에 사용 가능하며, 형광 특성은 498/517 nm입니다. Affinity chromatography로 정제되어 연구용으로 적합합니다.
- 카탈로그번호
- MAVSP-FITC
- 판매단위
- pk
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Thermo Fisher Scientific MAVS Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 500–540 of human mitochondrial antiviral-signaling protein isoform 1 (MAVS) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Two distinct signaling pathways activate host innate immunity against viral infection. One pathway relies on Toll-like receptor (TLR) family members, while the other uses RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA.
MAVS is a mitochondrial membrane protein critical in IFN-beta signaling, recruiting IRF-3 to RIG-I and activating NF-kappa-B. It interacts with innate immune pathway components such as TRIF, TRAF2, TRAF6, and kinases IKK-alpha, IKK-beta, and IKK-iota.
Cleavage of MAVS by Hepatitis C virus protease enables viral immune evasion. Multiple MAVS isoforms are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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