Thermo Fisher Scientific MECR Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MECR. Recombinant protein control fragment (Product #RP-93136). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MECR,uniProtId:Q9BV79-1,ncbiNodeId:9606,antigenRange:268-373,antigenLength:373,antigenImageFileName:PA5-55967_MECR_Q9BV79-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55967_MECR_Q9BV79-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643840

Product Specific Information

Immunogen sequence: SSTELLRQLA RGGTMVTYGG MAKQPVVASV SLLIFKDLKL RGFWLSQWKK DHSPDQFKEL ILTLCDLIRR GQLTAPACSQ VPLQDYQSAL EASMKPFISS KQILTM

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 87%.

Target Information

The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.