Thermo Fisher Scientific LRRFIP1 Polyclonal Antibody
LRRFIP1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, β-catenin 관련 신호전달 연구에 유용. 액상 형태로 제공되며 4°C 보관, 1년의 권장 유효기간을 가짐.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 50 and 100 of human Leucine Rich Repeat (in FLII) Interacting Protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein that mediates either induction or repression of TLR signaling.
Flap-1 directly interacts with β-catenin and activates β-catenin-dependent transcription activity.
Flap-1 or LRRFIP1 also binds the TNF- -308 promoter polymorphism site, suggesting its role in TNF- production regulation.
FLAP-1, LRRFIP2, and FLIIH coordinate inflammatory response after infection and may serve as novel targets in controlling agonist-induced TLR-mediated inflammatory and autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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