Thermo Fisher Scientific ATP6V0D1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
KLLFEGAGSN PGDKTLEDRF FEHEVKLNKL AFLNQFHFGV FYAFVKLKEQ

Sequence homology:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Target Information

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase dependent organelle acidification is necessary for intracellular processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase is composed of:

• V1 domain (cytosolic): Three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits (contains the ATP catalytic site)
• V0 domain (transmembrane): Five subunits (a, c, c’, c’’, and d)

This encoded protein represents the D subunit, which is ubiquitously expressed.
Additional isoforms of many V1 and V0 subunit proteins may be encoded by multiple genes or alternatively spliced transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.