Thermo Fisher Scientific PAX2 Recombinant Rabbit Monoclonal Antibody (JE25-49)
PAX2 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체입니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합하며, Human, Mouse, Rat 시료에 반응합니다. Protein A로 정제된 액상 항체로 장기 보관 시 -20°C에서 안정적입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE25-49 |
| Immunogen | Synthetic peptide within Human Pax2 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890483 |
Target Information
The PAX gene family encodes transcription factors that are active during early embryonic development. These genes contain a paired box domain that enables DNA binding and regulation of gene expression. Pax-2, in particular, is expressed in the developing kidney, especially in condensing metanephric mesenchyme and early epithelial structures. Expression of Pax-2 decreases as renal epithelium matures but persists in Wilms tumor, correlating with poorly differentiated epithelial cells. The Wilms tumor suppressor protein WT1 is known to repress Pax-2 transcription, indicating a regulatory relationship between these genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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