Thermo Fisher Scientific KCNMB1 Polyclonal Antibody
KCNMB1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Human, Mouse, Rat 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, Protein A로 정제된 1 mg/mL 액상 제품입니다. 연구용 전용 시약입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human KCNMB1, amino acids 10–80 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Potassium channels are ubiquitously expressed proteins that perform essential functions in both excitable and non-excitable cells. The large conductance, calcium-activated potassium channel (Maxi K⁺) is unique because its activation depends on both intracellular calcium increase and membrane depolarization. The Maxi K⁺ channel consists of an alpha homotetramer with voltage and calcium-binding domains, and in vascular smooth muscle, it associates with a beta-subunit in a 1:1 ratio. The beta-subunit lowers the calcium concentration required to open the channel by 5–10 fold, making it a potential therapeutic target for regulating blood flow and blood pressure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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