Thermo Fisher Scientific TTBK2 Polyclonal Antibody
인간 TTBK2 단백질을 인식하는 rabbit polyclonal antibody로, IHC(P)에서 1:20~1:100 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. TTBK2 관련 신경퇴행성 질환 및 항암 내성 연구에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TTBK2 Polyclonal Antibody
Thermo Fisher Scientific TTBK2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:20–1:100
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of human TTBK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2636713 |
Product Specific Information
The antibody detects endogenous levels of total TTBK2 protein.
Target Information
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates include tau and tubulin proteins.
Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and cerebellar and brainstem atrophy.
Studies indicate that elevated TTBK2 expression in kidney carcinoma and melanoma increases resistance to Sunitinib, while siRNA-mediated reduction of TTBK2 sensitizes these cells to treatment.
This suggests TTBK2 may serve as a resistance marker and potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.