Thermo Fisher Scientific CSF2 Monoclonal Antibody (OTI1A3), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The GM-CSF (CSF2) gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space.
This gene is located in the chromosome region 5q31, associated with interstitial deletions in 5q- syndrome and acute myelogenous leukemia.
It is part of a cluster including interleukins 4, 5, and 13, and plays a role in promoting tissue inflammation.
Elevated cytokine levels, including GM-CSF, have been observed in SARS-CoV-2–infected patients with acute respiratory distress syndrome.
Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.