Thermo Fisher Scientific NPRL2 Polyclonal Antibody
Human NPRL2 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제. PBS, 40% 글리세롤, 0.02% 나트륨 아지드 포함. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NPRL2. Recombinant protein control fragment (Product #RP-96301) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644777 |
Product Specific Information
Immunogen sequence:
KLIQFGLMKN LIRRLQKYPV RVTREEQSHP ARLYTGCHSY DEICCKTGMS YHELDERLEN DPNIIICW
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 97%
Target Information
NPRL2 (TUSC4) is a 380 amino acid protein containing a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver, and pancreas, with lower expression in lung, kidney, placenta, and heart. NPRL2 is expressed in most lung cancer cell lines and may function as a tumor suppressor. It may play roles in mismatch repair, cell cycle checkpoint signaling, and activation of apoptotic pathways. NPRL2 may enhance the therapeutic efficacy of chemotherapy drugs such as cisplatin by resensitizing resistant cells. The gene encoding NPRL2 is conserved across species and expressed as two isoforms due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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