Thermo Fisher Scientific Human IL-17A, Animal-Free Recombinant Protein, PeproTech
인간 IL-17A 재조합 단백질로 염증 반응 연구에 적합. E. coli 발현 시스템에서 생산되며 ≥98% 고순도 확보. IL-6 유도 활성 검증 완료. 보존제 무첨가, 동물성 성분 없는 형태로 제공. 연구용으로만 사용 가능.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (6 available)
Miscellaneous PubMed (Misc)
- Refer to publication (1 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Bovine, Human, Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA |
| Molecular Weight | 31.3 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥98% (by SDS-PAGE and HPLC) |
| Endotoxin Concentration | <0.1 EU/µg |
| Activity | Induces IL-6 production by NHDF cells (0.5–1.5 ng/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human IL-17A is a 31.3 kDa, disulfide-linked homodimer composed of two 137 amino acid polypeptide chains.
This product is shipped at ambient temperature. For storage, handling, and reconstitution details, refer to the lot-specific Certificate of Analysis.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer (136 amino acids) and a member of the IL-17 family (IL-17A–17F), signaling through the IL-17 receptor (IL-17R/CDw217).
It enhances ICAM-1 expression in human fibroblasts and stimulates epithelial, endothelial, and fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
In fibroblasts, IL-17A supports CD34+ hematopoietic progenitor proliferation and neutrophil maturation.
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, showing cross-species receptor recognition.
IL-17A regulates NF-κB and MAPK activities, stimulates IL-6 and COX-2 expression, and enhances nitric oxide (NO) production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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