Thermo Fisher Scientific alpha-1 Antitrypsin Polyclonal Antibody
Thermo Fisher Scientific의 alpha-1 Antitrypsin Polyclonal Antibody는 인간 시료에 반응하는 염소 유래 IgG 항체로, Western blot에 적합합니다. N-말단 펩타이드 면역원으로 제작되었으며, 고순도 액상 형태로 안정적인 신호 검출을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-QKTDTSHHDQDHP (aa 33–45) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933749 |
Product Specific Information
- The immunizing peptide represents the N terminus of the mature protein.
- Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Alpha-1-AT is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Deficiency of alpha-1-AT is associated with chronic obstructive lung disease (emphysema) and, less frequently, with hepatic cirrhosis in infants and respiratory distress of the newborn.
Increased alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation.
Serum levels of alpha-1-AT are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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