Thermo Fisher Scientific TCF19 Polyclonal Antibody

Thermo Fisher Scientific TCF19 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1–2 µg/mL
Publications: - [References not provided]

Product Specifications

Product Specific Information

• Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX25311-PEP).
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

TCF-19 (Transcription Factor 19), also known as SC1 or SC1-1, is a 345 amino acid protein containing one FHA domain, a proline-rich domain, and one PHD-type zinc finger.
It localizes to the nucleus and functions as a trans-activating factor involved in transcription of genes regulating late stages of cell cycle progression (G1 to S transition or entry into G2 and mitosis).
TCF-19 is preferentially expressed in the G1-S phase of the cell cycle.
The gene encoding TCF-19 localizes to a critical region on chromosome 6 associated with psoriasis vulgaris, a skin disorder characterized by hyperproliferation of epidermal cells.
This suggests that TCF-19 may play a role in the development of this disorder through regulation of late cell cycle-specific genes.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.