
Thermo Fisher Scientific NUMB Monoclonal Antibody (OTI6B2), TrueMAB
인간 NUMB 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot과 유세포분석에 적합. 고순도 친화 크로마토그래피 정제 제품으로, 액상 형태이며 PBS/BSA/glycerol buffer에 보관. 신경세포 분화 및 내포작용 연구용으로 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6B2 |
| Immunogen | Full length human recombinant protein of human NUMB produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.96 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells.
Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex.
NUMB is also expressed in postmitotic neurons and plays a role in axonal growth.
Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca²⁺ channel (VGCC) inhibitor or by Ca²⁺ chelator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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