ELK Biotechnology Cleaved-Caspase-4/5 p20 (D270/D311) rabbit pAb
Cleaved-Caspase-4/5 p20 (D270/D311) rabbit pAb는 인간 Caspase 4/5 유래 펩타이드에 대한 폴리클로날 항체로, apoptosis 연구에 적합합니다. WB 및 ELISA에 사용 가능하며, 높은 특이성과 안정성을 제공합니다. -20°C에서 1년간 보관 가능합니다.
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Cleaved-Caspase-4/5 p20 (D270/D311) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Cleaved-Caspase-4/5 p20 (D270/D311) rabbit pAb |
| Alternative Names | CASP4; ICH2; Caspase-4; CASP-4; ICE(rel)-II; Protease ICH-2; Protease TX; CASP5; ICH3; Caspase-5; CASP-5; ICE(rel)-III; Protease ICH-3; Protease TY |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 – 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caspase 4/5 (AA range: 221–270) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 47, 22 kD |
| GeneID (Human) | 837 |
| Human Swiss-Prot No. | P49662 / P51878 |
| Cellular Localization | Cytoplasm, cytosol, endoplasmic reticulum membrane (peripheral membrane protein, cytoplasmic side), mitochondrion, inflammasome, secreted. Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). |
| Species Reactivity | Human |
Background
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. (Provided by RefSeq, Jul 2008)
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