ELK Biotechnology Cleaved-Caspase-2 p18 (T325) rabbit pAb
Cleaved-Caspase-2 p18 (T325) rabbit polyclonal antibody로, 인간 Caspase-2 단백질의 절단형을 인식합니다. WB 및 ELISA에 적합하며, 세포 사멸 및 신경퇴행성 질환 연구에 활용 가능합니다. 고순도 IgG, -20°C 보관.
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Cleaved-Caspase-2 p18 (T325) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Caspase-2 p18 (T325) rabbit pAb |
| Alternative Names | CASP2; ICH1; NEDD2; Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase 2 p18 C-terminal (AA range: 276–325) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 22 kDa |
| Gene ID (Human) | 835 |
| Human Swiss-Prot No. | P42575 |
| Cellular Localization | Nucleus, cytoplasm, mitochondrion, cytosol, membrane |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer’s disease, Huntington’s disease, and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
[provided by RefSeq, Jan 2011]
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