ELK Biotechnology Cleaved-Caspase-1 p20 (N120) rabbit pAb
Cleaved-Caspase-1 p20 (N120) rabbit polyclonal antibody로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot과 ELISA에 적합하며, 세포자멸사 연구에 유용합니다. 합성 펩타이드 면역원으로 제작되었으며, -20°C에서 1년 보관 가능합니다.
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Cleaved-Caspase-1 p20 (N120) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Cleaved-Caspase-1 p20 (N120) rabbit pAb |
| Alternative Names | CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase 1 (AA range: 101–150) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kDa |
| Gene ID (Human) | 834 |
| Human Swiss-Prot No. | P29466 |
| Cellular Localization | Cytoplasm, Cell membrane |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene encodes a protein that belongs to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits (large and small), which dimerize to form the active enzyme.
This gene was identified by its ability to cleave and activate the inactive precursor of interleukin-1, a cytokine involved in inflammation, septic shock, and wound healing. It has been shown to induce apoptosis and may function in various developmental stages. Studies in mouse suggest a role in the pathogenesis of Huntington’s disease. Alternative splicing results in transcript variants encoding distinct isoforms.
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