
ELK Biotechnology Frizzled-6 rabbit pAb
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Product name: | Frizzled-6 rabbit pAb |
Alternative Names: | FZD6; Frizzled-6; Fz-6; hFz6 |
Applications: | WB;IHC;IF;ELISA |
Recommended Dilutions: | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
Immunogen: | The antiserum was produced against synthesized peptide derived from human FZD6. AA range:116-165 |
Storage: | -20°C/1 year |
Storage: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Concentration: | 1 mg/ml |
Observed Band: | 79kD |
GeneID(Human): | 8323 |
Human Swiss-Prot No: | O60353 |
Cellular localization: | Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cell surface . Apical cell membrane; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Colocalizes with FZD3 at the apical face of cells (By similarity). Localizes to the endoplasmic reticulum membrane in the presence of LMBR1L (By similarity). . |
Background: | frizzled class receptor 6(FZD6) Homo sapiens This gene represents a member of the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011], |
Species Reactivity: | Human;Rat;Mouse; |
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