ELK Biotechnology TNF-IP 8L2 rabbit pAb
TNFAIP8L2 단백질을 인식하는 토끼 다클론 항체로, WB 및 ELISA에 사용 가능. 면역 항상성 유지 및 염증 반응 조절 연구에 적합. Human, Mouse, Rat 반응성. -20°C에서 1년 보관.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology TNF-IP 8L2 rabbit pAb
ELK Biotechnology TNF-IP 8L2 Rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TNF-IP 8L2 rabbit pAb |
| Alternative Names | TNFAIP8L2; Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; Inflammation factor protein 20 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFAIP8L2 (AA range: 11-60) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kDa |
| GeneID (Human) | 79626 |
| Human Swiss-Prot No. | Q6P589 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Mouse; Rat |
Background
The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.
Function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negatively regulates Toll-like receptor and T-cell receptor functions, preventing hyperresponsiveness of the immune system. Inhibits Jun/AP1 and NF-kappa-B activation and promotes Fas-induced apoptosis.
Similarity: Belongs to the TNFAIP8 family, TNFAIP8L2 subfamily.
Subunit: May interact with CASP8; however, such interaction remains unclear as some studies could not reproduce this result (PubMed:19079267).
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.