ELK Biotechnology Tubulin α1/3/4 (phospho Tyr272) rabbit pAb
인산화된 Tyr272 부위에 특이적인 Tubulin α1/3/4 인식 polyclonal antibody. WB 및 ELISA에 적합하며, 인간·마우스·랫트 반응성. 세포질 및 세포골격에 위치한 α-튜불린 단백질 연구에 활용 가능.
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제품명
Tubulin α1/3/4 (phospho Tyr272) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TUBA1A; TUBA3; Tubulin alpha-1A chain; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain; TUBA1B; Tubulin alpha-1B chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain; TUBA1C; TUBA6; Tubulin alpha-1C |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human TUBA1/3/4 around the phosphorylation site of Tyr272 (AA range: 238–287) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50–55 kD |
| Gene ID (Human) | 7846 / 10376 / 84790 / 113457 / 7278 / 112714 / 7277 |
| Human Swiss-Prot No | Q71U36 / P68363 / Q9BQE3 / Q13748 / Q6PEY2 / P68366 |
| Cellular Localization | Cytoplasm, cytoskeleton |
| Species Reactivity | Human; Mouse; Rat |
Background
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta, and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly.
There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
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