ELK Biotechnology Splicing factor 1 (phospho Ser82) rabbit pAb
인산화된 Ser82 부위에 특이적인 Splicing factor 1 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 SF1 유래 합성 펩타이드로 제작된 rabbit polyclonal 항체이며, 핵 내 단백질 검출에 유용합니다. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관 가능.
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제품명
Splicing factor 1 (phospho Ser82) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SF1; ZFM1; ZNF162; Splicing factor 1; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Antiserum produced against synthesized peptide derived from human SF1 around the phosphorylation site of Ser82 (AA range: 48–97) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 68 kD |
| Gene ID (Human) | 7536 |
| Human Swiss-Prot No | Q15637 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Monkey |
Background
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3′ splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression.
The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Oct 2016]
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