ELK Biotechnology ZAP-70 (phospho Tyr315) rabbit pAb
ZAP-70 (phospho Tyr315) rabbit polyclonal antibody로 T세포 발달 및 활성화 연구에 적합. WB, IHC, IF, ELISA 등 다양한 응용 가능. 인산화 Tyr315 부위 기반 면역원 사용. 사람 및 생쥐 반응성. -20°C에서 1년 보관 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology ZAP-70 (phospho Tyr315) rabbit pAb
제품명
ZAP-70 (phospho Tyr315) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr315 (AA range: 281-330) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| Gene ID (Human) | 7535 |
| Human Swiss-Prot No. | P43403 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm, Cell membrane; Peripheral membrane protein. In quiescent T-lymphocytes, cytoplasmic. Upon TCR activation, recruited to plasma membrane via CD247/CD3Z interaction. Colocalizes with RHOH in the immunological synapse. RHOH is required for proper localization to membrane and cytoskeleton fractions in thymocytes (By similarity). |
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, playing a crucial role in T-cell development and lymphocyte activation. Upon T-cell antigen receptor (TCR) stimulation, it becomes phosphorylated on tyrosine residues and functions in the initial step of TCR-mediated signal transduction, in cooperation with Src family kinases Lck and Fyn. It is essential for thymocyte development. Mutations in this gene cause selective T-cell defects, leading to severe combined immunodeficiency with absence of CD8-positive T-cells. Two transcript variants encoding different isoforms have been identified (RefSeq, Jul 2008).
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.