ELK Biotechnology ZAP-70 (phospho Tyr319) rabbit pAb
ZAP-70 (phospho Tyr319) rabbit pAb는 인산화된 ZAP-70 단백질을 검출하는 폴리클로날 항체로, T세포 신호전달 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 사람·마우스·랫에서 반응합니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
ZAP-70 (phospho Tyr319) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr319 (AA range: 286–335) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kDa |
| Gene ID (Human) | 7535 |
| Human Swiss-Prot No. | P43403 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; Cell membrane; Peripheral membrane protein. In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, recruited to the plasma membrane via CD247/CD3Z interaction. Colocalizes with RHOH in the immunological synapse. RHOH is required for proper localization to the membrane and cytoskeleton in thymocytes (By similarity). |
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, which plays a key role in T-cell development and lymphocyte activation. The enzyme becomes phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation and functions in the initial step of TCR-mediated signal transduction together with Src family kinases Lck and Fyn. It is essential for thymocyte development, and mutations in this gene cause selective T-cell defects, leading to severe combined immunodeficiency characterized by the absence of CD8-positive T-cells. Two transcript variants encoding different isoforms have been identified (RefSeq, Jul 2008).
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