ELK Biotechnology Ku-80 (phospho Thr714) rabbit pAb
Ku-80 (phospho Thr714) rabbit polyclonal antibody로 DNA 손상 복구 관련 단백질 Ku80의 인산화 형태를 검출. WB, IHC, IF, ELISA에 사용 가능. 인산화 Thr714 부위 특이적 항체로 핵 내 Ku 복합체 연구에 적합. 고순도 IgG, -20°C에서 1년 보관.
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제품명
Ku-80 (phospho Thr714) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Ku80 around the phosphorylation site of Thr714 (AA range: 683–732) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 83 kDa |
| GeneID (Human) | 7520 |
| Human Swiss-Prot No | P13010 |
| Cellular Localization | Nucleus; Nucleus, nucleolus; Chromosome |
| Species Reactivity | Human; Monkey |
Background
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein, also known as ATP-dependent DNA helicase II or DNA repair protein XRCC5. Ku acts as the DNA-binding component of the DNA-dependent protein kinase and functions together with the DNA ligase IV–XRCC4 complex in repairing DNA double-strand breaks via non-homologous end joining and in V(D)J recombination. This gene complements Chinese hamster xrs-6 mutant cells defective in DNA double-strand break repair and V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer susceptibility and radiosensitivity.
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