ELK Biotechnology WASP (phospho Tyr290) rabbit pAb
WASP (phospho Tyr290) rabbit pAb는 인간 및 마우스 시료에서 WAS 단백질의 Tyr290 인산화 형태를 검출하는 다클론 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며, 고특이성과 재현성을 제공합니다. 세포골격 신호전달 연구에 적합합니다.
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WASP (phospho Tyr290) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | WAS; IMD2; Wiskott-Aldrich syndrome protein; WASp |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human WASP around the phosphorylation site of Tyr290 (AA range: 256–305) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| Gene ID (Human) | 7454 |
| Human Swiss-Prot No. | P42768 |
| Cellular Localization | Cytoplasm, cytoskeleton, nucleus |
| Species Reactivity | Human; Mouse |
Background
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structures and are involved in signal transduction from cell surface receptors to the actin cytoskeleton. These proteins contain multiple motifs, indicating regulation by various stimuli and interactions with multiple proteins. Studies show that WAS proteins associate with the small GTPase Cdc42, which regulates actin filament formation, and the cytoskeletal organizing complex Arp2/3.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked recessive disease characterized by immune dysregulation and microthrombocytopenia, caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells, which exhibit signaling and cytoskeletal abnormalities in WAS patients.
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