ELK Biotechnology Ezrin (phospho Tyr146) rabbit pAb
인산화 Tyr146 부위를 인식하는 Ezrin rabbit polyclonal antibody로, WB와 ELISA에 적합합니다. 세포막과 세포골격 간 상호작용 연구에 유용하며, 인간·마우스·랫트 시료에 반응합니다. -20°C에서 1년 보관 가능합니다.
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Ezrin (phospho Tyr146) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Ezrin (phospho Tyr146) rabbit pAb |
| Alternative Names | EZR; VIL2; Ezrin; Cytovillin; Villin-2; p81 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Ezrin around the phosphorylation site of Tyr146. AA range: 111-160 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 69 kD |
| GeneID (Human) | 7430 |
| Human Swiss-Prot No. | P15311 |
| Species Reactivity | Human; Mouse; Rat |
Cellular Localization
Apical cell membrane; Peripheral membrane protein (cytoplasmic side); Cell projection; Microvillus membrane; Ruffle membrane; Cytoplasm (cell cortex and cytoskeleton). Localization to the apical membrane of parietal cells depends on interaction with PALS1. Also localizes to astrocyte extensions and peripheral processes (By similarity).
Background
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, it serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration, and organization, and has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified. Alternatively spliced variants have also been described (RefSeq, Jul 2008).
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