ELK Biotechnology VHL rabbit pAb
VHL 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA에 적합합니다. 인간 유래 합성 펩타이드로 면역화되었으며, HIF 분해 관련 연구에 유용합니다. 사람, 마우스, 랫트 시료에 반응합니다.
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제품명
VHL rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | VHL; Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VHL (AA range: 34-83) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 7428 |
| Human Swiss-Prot No | P40337 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform 1: Cytoplasm, membrane (peripheral membrane protein), nucleus. Predominantly cytoplasmic, with smaller amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane. Isoform 3: Cytoplasm, nucleus. Equally distributed between nucleus and cytoplasm, not membrane-associated. |
Background
Von Hippel-Lindau tumor suppressor (VHL) is associated with the dominantly inherited familial cancer syndrome known as Von Hippel-Lindau syndrome (VHL). Germline mutations in this gene cause susceptibility to various malignant and benign tumors. The VHL protein forms a complex with elongin B, elongin C, and cullin-2, exhibiting ubiquitin ligase E3 activity. It mediates ubiquitination and degradation of hypoxia-inducible factor (HIF), a key transcription factor regulating oxygen-dependent gene expression. RNA polymerase II subunit POLR2G/RPB7 is also a reported target. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
[Provided by RefSeq, Jul 2008]
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