ELK Biotechnology VDR (phospho Ser208) rabbit pAb
비타민 D3 수용체(VDR) Ser208 인산화 부위를 인식하는 토끼 폴리클로날 항체로, WB, IF, ELISA에 적합합니다. 핵 및 세포질에서 발현되는 VDR 단백질 검출에 유용하며, 인산화 관련 신호전달 연구에 활용 가능합니다.
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VDR (phospho Ser208) rabbit pAb
제품 개요
본 항체는 인간 Vitamin D Receptor(VDR)의 Ser208 인산화 부위를 인식하도록 합성된 펩타이드로부터 제작된 토끼 폴리클로날 항체입니다. VDR은 핵 호르몬 수용체로, 비타민 D3 및 2차 담즙산 lithocholic acid의 수용체로 기능하며, 다양한 대사 및 면역 반응 조절에 관여합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | VDR (phospho Ser208) rabbit pAb |
| Alternative Names | VDR; NR1I1; Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IF: 1/200–1/1000 ELISA: 1/10000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human Vitamin D Receptor around the phosphorylation site of Ser208 (AA range: 181–230) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kDa |
| Gene ID (Human) | 7421 |
| Human Swiss-Prot No. | P11473 |
| Cellular Localization | Nucleus, Cytoplasm. Mainly localized in the nucleus; localization enhanced by vitamin D3 (PubMed:28698609, 12145331). |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene encodes the nuclear hormone receptor for vitamin D3, which also acts as a receptor for the secondary bile acid lithocholic acid. The receptor is part of the nuclear transcriptional regulatory factor family, showing similarity to steroid and thyroid hormone receptors. Its downstream targets are mainly involved in mineral metabolism but also regulate immune response and cancer-related pathways. Mutations in this gene are linked to type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon can lead to an alternative translation start site, and alternative splicing results in multiple transcript variants encoding different proteins. (RefSeq, Feb 2011)
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