ELK Biotechnology VCP (phospho Ser352) rabbit pAb
VCP 단백질의 Ser352 인산화 형태를 인식하는 rabbit polyclonal antibody. Western blot 및 ELISA에 적합하며, 세포 내 다양한 위치에서 발현되는 VCP 연구에 활용 가능. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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ELK Biotechnology VCP (phospho Ser352) rabbit pAb
제품 개요
VCP (Valosin-containing protein)의 Ser352 인산화 부위를 인식하는 rabbit polyclonal antibody로, 세포 내 단백질 이동 및 스트레스 반응 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | VCP (phospho Ser352) rabbit pAb |
| Alternative Names | VCP; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit; Valosin-containing protein; VCP |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VCP around the phosphorylation site of Ser352 (AA range: 318–367) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85 kD |
| GeneID (Human) | 7415 |
| Human Swiss-Prot No | P55072 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Cellular Localization
Cytoplasm, cytosol, endoplasmic reticulum, nucleus, and stress granules. Present in neuronal inclusion bodies found in motor neurons from amyotrophic lateral sclerosis patients and Lewy bodies in Parkinson disease. Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Also recruited to DNA double-strand break sites, stalled replication forks, and damaged lysosomes decorated with K48-linked ubiquitin chains. Colocalizes with TIA1, ZFAND1, and G3BP1 in cytoplasmic stress granules.
Background
Valosin-containing protein (VCP) in Homo sapiens is a member of a family of ATP-binding proteins involved in vesicle transport, 26S proteasome function, and peroxisome assembly. This structural protein associates with clathrin and heat-shock protein Hsc70 to form complexes. It participates in cellular events regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
[provided by RefSeq, Jul 2008]
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