ELK Biotechnology Vav1 (phospho Tyr174) rabbit pAb
Vav1 단백질의 Tyr174 인산화 부위를 인식하는 토끼 폴리클로날 항체. Western blot 및 ELISA에 적합하며, 인간·마우스·랫트 반응성. 세포 내 시그널링 및 혈구세포 발달 연구에 활용 가능.
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제품명
Vav1 (phospho Tyr174) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | VAV1; VAV; Proto-oncogene vav |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human VAV1 around the phosphorylation site of Tyr174 (AA range: 141–190) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 98 kD |
| Gene ID (Human) | 7409 |
| Human Swiss-Prot No. | P15498 |
| Cellular Localization | Intracellular, cytosol, plasma membrane, cell-cell junction |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements, and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(Provided by RefSeq, Apr 2012)
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