ELK Biotechnology Vav (phospho Tyr174) rabbit pAb
Vav 단백질의 인산화 Tyr174 부위를 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포 내 신호전달 및 면역세포 발달 연구에 적합하며, 높은 특이성과 안정성을 제공. -20°C에서 1년 보관 가능.
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제품명
Vav (phospho Tyr174) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | VAV1; VAV; Proto-oncogene vav |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Vav (phospho Tyr174) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kD |
| Gene ID (Human) | 7409 |
| Human Swiss-Prot No. | P15498 |
| Cellular Localization | Intracellular, cytosol, plasma membrane, cell-cell junction |
| Species Reactivity | Human; Mouse; Rat |
배경 (Background)
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
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