ELK Biotechnology HIRA rabbit pAb
Human HIRA 단백질을 인식하는 rabbit polyclonal antibody로, IHC·IF·ELISA에 사용 가능. 핵 및 PML body에 주로 위치하며, 노화 관련 이형염색질 형성 연구에 적합. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
HIRA rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HIRA; DGCR1; HIR; TUPLE1; Protein HIRA; TUP1-like enhancer of split protein 1 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HIRA (AA range: 521-570) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 7290 |
| Human Swiss-Prot No | P54198 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Nucleus; PML body. Primarily localized to the nucleus and to PML bodies prior to onset of senescence. |
Background
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin.
It plays an important role in the formation of senescence-associated heterochromatin foci, which mediate irreversible cell cycle changes in senescent cells.
HIRA is considered the primary candidate gene in haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production may disrupt normal embryonic development.
[provided by RefSeq, Jul 2008]
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