ELK Biotechnology p53 (phospho Ser376) rabbit pAb
인간 p53 단백질의 Ser376 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합합니다. 세포 내 종양 억제 단백질 연구에 활용되며, 고순도 IgG 형태로 제공됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
p53 (phospho Ser376) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human p53 around the phosphorylation site of Ser376 (AA range: 344–393) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 53 kD |
| GeneID (Human) | 7157 |
| Human Swiss-Prot No. | P04637 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies together with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) and in response to mitomycin C treatment (PubMed:27323408).
- Isoform 1: Predominantly nuclear but localizes to cytoplasm when expressed with isoform 4
- Isoform 2: Mainly nuclear with minor cytoplasmic staining
- Isoform 3: Nuclear in most cells, cytoplasmic in some
- Isoform 4: Predominantly nuclear but translocates to cytoplasm
Background
Tumor protein p53 (TP53) in Homo sapiens encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.
The encoded protein responds to diverse cellular stresses to regulate expression of target genes, inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes.
Mutations in this gene are associated with various human cancers, including hereditary cancers such as Li-Fraumeni syndrome.
Alternative splicing and alternate promoters result in multiple transcript variants and isoforms. Additional isoforms may arise from alternate translation initiation codons (PMIDs: 12032546, 20937277).
[provided by RefSeq, Feb 2013]
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