ELK Biotechnology Topo IIβ rabbit pAb
Topo IIβ rabbit pAb는 인간 및 생쥐에서 반응하는 폴리클로날 항체로, DNA 토포이소머라제 IIβ를 검출합니다. WB, IHC, IF, ELISA에 사용 가능하며 높은 특이성과 안정성을 제공합니다. 핵 내 단백질 연구에 적합합니다.
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제품명
Topo IIβ rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| 공급업체 | ELK Biotechnology |
| 대체명 | TOP2B; DNA topoisomerase 2-beta; DNA topoisomerase II; beta isozyme |
| 클론성(Clonality) | Polyclonal |
| 아이소타입(Isotype) | IgG |
| 농도(Concentration) | 1 mg/ml |
| 관찰 밴드(Observed Band) | 183 kD |
| GeneID (Human) | 7155 |
| Human Swiss-Prot No | Q02880 |
| 반응 종(Species Reactivity) | Human; Mouse |
적용 분야(Applications)
- WB (Western Blot)
- IHC (Immunohistochemistry)
- IF (Immunofluorescence)
- ELISA
권장 희석 배율(Recommended Dilutions)
| 실험 종류 | 희석 배율 |
|---|---|
| Western Blot | 1/500 – 1/2000 |
| Immunohistochemistry | 1/100 – 1/300 |
| ELISA | 1/20000 |
| 기타 | Not yet tested in other applications |
면역원(Immunogen)
The antiserum was produced against a synthesized peptide derived from human TOP2B.
Amino acid range: 1–50
저장 조건(Storage)
- Rabbit origin
- −20°C, 1년 보관 가능
세포 내 위치(Cellular Localization)
Nucleus, nucleolus, nucleoplasm
배경 정보(Background)
This gene encodes a DNA topoisomerase that controls and alters the topologic states of DNA during transcription.
It is involved in chromosome condensation, chromatid separation, and relief of torsional stress during DNA transcription and replication.
The enzyme catalyzes transient breaking and rejoining of duplex DNA strands, allowing them to pass through one another and alter DNA topology.
Two forms of this enzyme exist, likely products of a gene duplication event: the beta form localized to chromosome 3, and the alpha form to chromosome 17.
This gene serves as a target for several anticancer agents, and mutations can lead to drug resistance. Reduced activity may be associated with pathological conditions.
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