ELK Biotechnology Topo IIα (phospho Ser1106) rabbit pAb
Topo IIα (phospho Ser1106) rabbit polyclonal antibody로, 인간 TOP2A 인산화 부위를 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며, 세포 핵 및 세포질에서 발현을 검출할 수 있습니다. 항암제 표적 연구 및 DNA 복제 관련 연구에 적합합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Topo IIα (phospho Ser1106) rabbit pAb
Topo IIα (phospho Ser1106) Rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Topo IIα (phospho Ser1106) rabbit pAb |
| Alternative Names | TOP2A; TOP2; DNA topoisomerase 2-alpha; DNA topoisomerase II; alpha isozyme |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TOP2A around the phosphorylation site of Ser1106 (AA range: 1081–1130) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 174 kDa |
| Gene ID (Human) | 7153 |
| Human Swiss-Prot No. | P11388 |
| Cellular Localization | Cytoplasm; Nucleus; Nucleoplasm; Nucleolus |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in chromosome condensation, chromatid separation, and the relief of torsional stress during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA, allowing the strands to pass through one another and alter DNA topology. Two forms of this enzyme exist, alpha and beta, likely products of a gene duplication event. The alpha form is localized to chromosome 17, while the beta form is on chromosome 3. This enzyme functions as the target for several anticancer agents, and various mutations in this gene have been associated with drug resistance. Reduced activity of this enzyme may also play a role in abnormal DNA processing.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.