ELK Biotechnology Topo IIα (phospho Thr1343) rabbit pAb

Topo IIα (phospho Thr1343) rabbit pAb

제품 개요

Topo IIα (phospho Thr1343) rabbit polyclonal antibody는 인간 TOP2A 단백질의 Thr1343 인산화 부위를 인식하도록 제작된 항체로, DNA 구조 조절 및 전사 과정에서 중요한 역할을 하는 효소를 검출할 수 있습니다.

제품 정보

Background

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA, allowing the strands to pass through one another and thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The alpha form is localized to chromosome 17, while the beta form is localized to chromosome 3. This enzyme is a target for several anticancer agents, and mutations in this gene have been associated with drug resistance. Reduced activity may also play a role in certain pathological conditions.