ELK Biotechnology TRβ1 (phospho Ser142) rabbit pAb
TRβ1 (phospho Ser142) rabbit pAb는 인산화된 TRβ1 단백질을 검출하는 폴리클로날 항체입니다. WB와 ELISA에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 핵 내 위치 단백질 분석에 유용하며, -20°C에서 1년간 보관 가능합니다.
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제품명
TRβ1 (phospho Ser142) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | THRB; ERBA2; NR1A2; THR1; Thyroid hormone receptor beta; Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TR-beta1 around the phosphorylation site of Ser142 (AA range: 116-165) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kD |
| Gene ID (Human) | 7068 |
| Human Swiss-Prot No. | P10828 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of several receptors for thyroid hormone and mediates the biological activities of thyroid hormone. Knockout studies in mice suggest that different receptors, while partially redundant, may mediate distinct thyroid hormone functions. Mutations in this gene can cause generalized thyroid hormone resistance (GTHR), characterized by goiter and elevated circulating thyroid hormone (T3-T4) with normal or slightly elevated TSH. Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
[Provided by RefSeq, Jul 2008]
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