ELK Biotechnology TERT (phospho Ser227) rabbit pAb
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인산화된 Ser227 부위를 인식하는 TERT rabbit polyclonal antibody. 인간, 생쥐, 랫드 시료에 반응. IF 및 ELISA에 사용 가능하며, 세포 내 TERT 단백질의 위치 및 발현 연구에 적합. -20°C에서 1년 보관 가능.
브랜드: ELK Biotechnology
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제품명
TERT (phospho Ser227) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TERT; EST2; TCS1; TRT; Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2 |
| Applications | IF; ELISA |
| Recommended Dilutions | Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Telomerase around the phosphorylation site of Ser227. AA range: 196–245 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 7015 |
| Human Swiss-Prot No. | O14746 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Nucleus, nucleolus, nucleoplasm, chromosome (telomere), cytoplasm, PML body. Shuttling between nucleus and cytoplasm depends on cell cycle, phosphorylation states, transformation, and DNA damage. Diffuse localization in nucleoplasm, enriched in nucleoli of certain cell types. Translocated to cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT. |
| Background | Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. It consists of a protein component with reverse transcriptase activity and an RNA component serving as a template. Telomerase expression is normally repressed in somatic cells, leading to telomere shortening and cellular senescence. Deregulation may contribute to oncogenesis. Studies in mice suggest telomerase also participates in chromosomal repair via de novo synthesis of telomere repeats at double-stranded breaks. Alternatively spliced variants encoding different isoforms have been identified. |
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