ELK Biotechnology Tie-2 rabbit pAb

제품명

Tie-2 rabbit pAb

제품 설명

Tie-2는 혈관 내피세포의 발달과 안정화에 중요한 역할을 하는 수용체 티로신 키나아제로, 본 항체는 Tie-2 단백질을 특이적으로 인식하는 토끼 폴리클로날 항체입니다. Angiopoietin-1 수용체로도 알려져 있으며, 혈관 형성과 관련된 신호전달 연구에 유용합니다.

제품 정보

세포 내 위치 (Cellular Localization)

Cell membrane; Single-pass type I membrane protein.
Cell junction, focal adhesion, cytoplasm, cytoskeleton, and secreted forms observed.
Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119).
Colocalizes with actin cytoskeleton and stress fibers during cell spreading.
Recruited to the lower surface of migrating cells, especially at the rear end.
Proteolytic processing yields a soluble extracellular domain that is secreted (PubMed:11806244).

Background

This gene encodes a receptor belonging to the protein tyrosine kinase Tie2 family. The encoded protein features a unique extracellular region with two immunoglobulin-like domains, three EGF-like domains, and three fibronectin type III repeats. Angiopoietin-1 binds to this receptor, mediating a signaling pathway essential for embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants, though the full-length nature of some variants remains unknown. [RefSeq, Feb 2014]