ELK Biotechnology Tie-2 (phospho Tyr1102) rabbit pAb
Tie-2 (phospho Tyr1102) rabbit pAb는 인산화된 Tyr1102 부위를 인식하는 폴리클로날 항체로, IHC, IF, ELISA 등에 사용됩니다. 인간 및 생쥐 시료에 반응하며, 혈관 발달 관련 신호전달 연구에 적합합니다. -20°C에서 1년간 보관 가능합니다.
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제품명
Tie-2 (phospho Tyr1102) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TEK; TIE2; VMCM; VMCM1; Angiopoietin-1 receptor; Endothelial tyrosine kinase; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | WB: 1:500–2000; IHC: 1:100–1:300; ELISA: 1:40000. Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1102 (AA range: 1068–1117) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 7010 |
| Human Swiss-Prot No. | Q02763 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; Single-pass type I membrane protein.
Cell junction; focal adhesion; Cytoplasm, cytoskeleton; Secreted.
Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119).
Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading.
Recruited to the lower surface of migrating cells, especially the rear end of the cell.
Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244).
배경 (Background)
This gene encodes a receptor belonging to the protein tyrosine kinase Tie2 family.
The encoded protein has a unique extracellular region containing two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains, and three fibronectin type III repeats.
Angiopoietin-1 binds to this receptor, mediating a signaling pathway essential for embryonic vascular development.
Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes.
Alternative splicing results in multiple transcript variants, though some full-length forms remain uncharacterized.
[provided by RefSeq, Feb 2014]
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