ELK Biotechnology Tie-2 (phospho Tyr1108) rabbit pAb
인간 및 생쥐 시료에 반응하는 Tie-2 인산화형(Tyr1108) 특이 토끼 다클론 항체. WB, ELISA, IHC에 적합하며 고품질 신호 검출 가능. 세포막 및 세포골격 위치 단백질 연구에 유용. -20°C에서 1년 보관 가능.
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제품명
Tie-2 (phospho Tyr1108) rabbit pAb
제품 개요
이 항체는 인간 TIE2 단백질의 Tyr1108 인산화 부위 주변에서 합성된 펩타이드로부터 제작된 토끼 다클론 항체입니다. 혈관 내피세포 관련 신호전달 연구에 사용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TEK; TIE2; VMCM; VMCM1; Angiopoietin-1 receptor; Endothelial tyrosine kinase; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1108 (AA range: 1074–1123) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150 kDa |
| Gene ID (Human) | 7010 |
| Human Swiss-Prot No. | Q02763 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Cell membrane; Single-pass type I membrane protein.
Cell junction; focal adhesion; Cytoplasm, cytoskeleton; Secreted.
Recruited to cell-cell contacts in quiescent endothelial cells.
Colocalizes with actin cytoskeleton and stress fibers during cell spreading.
Recruited to the lower surface of migrating cells, especially the rear end.
Proteolytic processing produces a soluble extracellular domain that is secreted.
Background
This gene encodes a receptor belonging to the Tie2 family of protein tyrosine kinases. The encoded protein has a unique extracellular region containing two immunoglobulin-like domains, three EGF-like domains, and three fibronectin type III repeats. Angiopoietin-1 binds to this receptor to mediate signaling involved in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants.
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