ELK Biotechnology TCP-1 α rabbit pAb
TCP-1 α rabbit polyclonal antibody for detection of chaperonin TCP1 complex proteins. Suitable for WB and ELISA. Recognizes human, mouse, and rat TCP-1 α with high specificity. Stable for 1 year at -20°C. Concentration 1 mg/ml.
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TCP-1 α Rabbit Polyclonal Antibody
제품 개요
TCP-1 α rabbit polyclonal antibody는 TCP1 복합체(CCT, TRiC)의 α 서브유닛을 인식하는 항체로, 분자 샤페론 단백질 연구에 적합합니다. 이 복합체는 8개의 서로 다른 단백질로 구성된 두 개의 동일한 링 구조를 가지며, ATP 의존적으로 폴리펩타이드의 접힘을 돕습니다. Actin과 tubulin 등 다양한 단백질의 접힘에 관여합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TCP-1 α rabbit pAb |
| Alternative Names | TCP1; CCT1; CCTA; T-complex protein 1 subunit alpha; TCP-1-alpha; CCT-alpha |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human TCP-1 α |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 6950 |
| Human Swiss-Prot No | P17987 |
| Cellular Localization | Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. (RefSeq, Jun 2010)
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