ELK Biotechnology TAL1 rabbit pAb
TAL1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 및 생쥐 시료에 반응하며 핵에 주로 위치. 혈액세포 분화 연구 및 백혈병 관련 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
TAL1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human TAL-1 (AA range: 96–145) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kDa |
| Gene ID (Human) | 6886 |
| Human Swiss-Prot No. | P17542 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
Alternative products: The splicing pattern is cell-lineage dependent.
Disease: A chromosomal aberration involving TAL1 may cause some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
Domain: The helix-loop-helix domain is necessary and sufficient for interaction with DRG1.
Function: Implicated in the genesis of hemopoietic malignancies; may play an important role in hemopoietic differentiation; serves as a positive regulator of erythroid differentiation.
PTM: Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia. Ubiquitinated following hypoxia-dependent phosphorylation of Ser-122, targeting the protein for rapid degradation via the ubiquitin system.
Similarity: Contains one basic helix-loop-helix (bHLH) domain.
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to LMO2 and DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed of CBFA2T3, LDB1, TAL1, and TCF3.
Tissue specificity: Leukemic stem cell.
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