ELK Biotechnology TAF II p18 rabbit pAb

제품명

TAF II p18 rabbit pAb

제품 개요

TAF II p18(또는 TAF13)은 RNA polymerase II 전사 개시 복합체의 구성 요소로, 전사 조절 및 프로모터 인식에 중요한 역할을 합니다. 본 항체는 인간 TAF13 유래 합성 펩타이드(AA 71-120)를 면역원으로 하여 제작된 토끼 폴리클로날 항체입니다.

상세 정보

Background

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition, or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFII.