ELK Biotechnology TAF II p135/p105 rabbit pAb
TAF II p135/p105 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 및 생쥐 시료에 반응하며, 핵 내 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
TAF II p135/p105 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TAF II p135/p105 rabbit pAb |
| Alternative Names | TAF4; TAF2C; TAF2C1; TAF4A; TAFII130; TAFII135; Transcription initiation factor TFIID subunit 4; RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; Transcription initiation factor TFIID 130 kDa subunit; TAF(II)130 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TAF4 (AA range: 941–990) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 110 kD |
| Gene ID (Human) | 6874 / 6875 |
| Human Swiss-Prot No. | O00268 / Q92750 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.
TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors (TAFs).
TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition, or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.
This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid and thyroid hormone.
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