ELK Biotechnology TAF II p250 rabbit pAb
인간 TAF1 단백질 유래 펩타이드로 면역한 rabbit polyclonal antibody. IHC, IF, ELISA에 사용 가능하며 핵 내 TAF II p250 단백질 검출에 적합. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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제품명
TAF II p250 rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TAF1; BA2R; CCG1; CCGS; TAF2A; Transcription initiation factor TFIID subunit 1; Cell cycle gene 1 protein; TBP-associated factor 250 kDa; p250; Transcription initiation factor TFIID 250 kDa subunit; TAF(II)250; TAFII-250; TAFII250 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human TAF1 (AA range: 1131–1180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 6872 |
| Human Swiss-Prot No | P21675 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.
TFIID is composed of the TATA-binding protein (TBP) and evolutionarily conserved proteins known as TBP-associated factors (TAFs).
TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition, or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.
This gene encodes the largest subunit of TFIID, which binds to core promoter sequences encompassing the transcription start site.
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