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ELK Biotechnology LKB1 (phospho Thr189) rabbit pAb
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LKB1 단백질의 Thr189 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB와 ELISA에 사용 가능. 세포 극성 조절 및 종양 억제 연구에 적합하며, 인체 및 마우스 시료에 반응. -20°C에서 1년 보관 가능.
- 판매단위
- pk
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ELK Biotechnology ES7309-100UL LKB1 (phospho Thr189) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES7309-50UL LKB1 (phospho Thr189) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology LKB1 (phospho Thr189) rabbit pAb
제품명
LKB1 (phospho Thr189) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | STK11; LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; hLKB1; Renal carcinoma antigen NY-REN-19 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LKB1 around the phosphorylation site of Thr189 (AA range: 155–204) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kD |
| Gene ID (Human) | 6794 |
| Human Swiss-Prot No. | Q15831 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Nucleus, Cytoplasm, Membrane, Mitochondrion. A small fraction localizes at membranes (By similarity). Relocates to cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. Isoform 2: Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment. |
Background
This gene encodes a member of the serine/threonine kinase family that regulates cell polarity and functions as a tumor suppressor. Mutations in this gene are associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by gastrointestinal polyps, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants have been observed but not thoroughly characterized. (RefSeq, Jul 2008)
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