ELK Biotechnology Stat5a (phospho Ser780) rabbit pAb
STAT5A의 Ser780 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, IP, ELISA에 사용 가능. 세포 내 STAT5A 인산화 연구 및 신호전달 경로 분석에 적합. 인간, 마우스, 랫트 반응성.
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Stat5a (phospho Ser780) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Stat5a (phospho Ser780) rabbit pAb |
| Alternative Names | STAT5A; STAT5; Signal transducer and activator of transcription 5A |
| Applications | WB; IHC; IF; IP; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human STAT5A around the phosphorylation site of Ser780. AA range: 745–794 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 91 kDa |
| GeneID (Human) | 6776 |
| Human Swiss-Prot No | P42229 |
| Cellular Localization | Cytoplasm, Nucleus. Translocated into the nucleus in response to phosphorylation. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and is essential for tumorigenesis. The mouse counterpart induces expression of BCL2L1/BCL-X(L), suggesting an anti-apoptotic function. Alternatively spliced transcript variants have been identified.
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