ELK Biotechnology Stat1 (phospho Ser727) rabbit pAb
STAT1 (phospho Ser727) rabbit polyclonal antibody for detection of phosphorylated STAT1 in WB, IHC, IF, and ELISA. Recognizes human, mouse, and rat STAT1. High specificity and stability with -20°C storage for up to 1 year.
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Stat1 (phospho Ser727) Rabbit Polyclonal Antibody
제품 개요
STAT1 (phospho Ser727) rabbit pAb는 인간 STAT1 단백질의 Ser727 인산화 부위를 인식하는 폴리클로날 항체입니다. 다양한 세포 신호 전달 경로에서 STAT1 활성화 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Stat1 (phospho Ser727) rabbit pAb |
| Alternative Names | STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human STAT1 around phosphorylation site of Ser727 (AA range: 694–743) |
| Host | Rabbit |
| Storage | -20°C, stable for 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 87 kDa |
| Gene ID (Human) | 6772 |
| Human Swiss-Prot No. | P42224 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm and nucleus. Translocated into the nucleus upon tyrosine phosphorylation and dimerization in response to IFN-γ and signaling by activated FGFR1–4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and nuclear translocation (PubMed:28753426). Also translocates into the nucleus in response to interferon-β stimulation (PubMed:26479788).
배경 (Background)
The STAT1 protein is a member of the STAT family, activated by cytokines and growth factors. Upon phosphorylation, STAT1 forms homo- or heterodimers that translocate to the nucleus and act as transcription activators. It mediates gene expression essential for cell viability and immune response. Activated by interferon-α, interferon-γ, EGF, PDGF, and IL6. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [RefSeq, Jul 2008]
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