ELK Biotechnology SRPK1 rabbit pAb
SRPK1 단백질을 인식하는 토끼 다클론 항체로, WB 및 ELISA에 적합합니다. 인간 SRPK1 유래 합성 펩타이드로 면역화되었으며, 세포 내 스플라이싱 인자 조절 연구에 활용됩니다. 고농도 IgG 형태로 -20°C에서 1년간 안정적으로 보관 가능합니다.
- 판매단위
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SRPK1 rabbit pAb
제품 개요
SRPK1 rabbit pAb는 인간 SRPK1 단백질을 인식하는 토끼 다클론 항체로, 세포 내 스플라이싱 인자 조절 연구에 적합합니다. Western blot 및 ELISA 분석에 사용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SRPK1 rabbit pAb |
| Alternative Names | SRPK1; SRSF protein kinase 1; SFRS protein kinase 1; Serine/arginine-rich protein-specific kinase 1; SR-protein-specific kinase 1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SRPK1 (AA range: 521–570) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 95 kD |
| GeneID (Human) | 6732 |
| Human Swiss-Prot No. | Q96SB4 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Isoform 2: Cytoplasm, Nucleus, Nucleus matrix, Microsome. Shuttles between the nucleus and cytoplasm.
Inhibition of Hsp90 ATPase activity, osmotic stress, and interaction with HHV-1 ICP27 protein induce translocation to the nucleus.
KAT5/TIP60 inhibits nuclear translocation. - Isoform 1: Cytoplasm, Nucleus matrix, Microsome. Mainly localized in the microsomal fraction and cytoplasm, and to a lesser extent in the nuclear matrix.
- General localization: Cytoplasm, Nucleus (nucleoplasm, speckle), Chromosome. Preferentially localizes to promoter regions of gene coding areas.
배경 (Background)
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors.
The protein localizes to the nucleus and cytoplasm and plays a role in regulation of constitutive and alternative splicing by controlling the intracellular localization of splicing factors.
Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described, but their full-length nature has not been determined.
[provided by RefSeq, Jul 2010]
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