ELK Biotechnology SRF (phospho Ser77) rabbit pAb
SRF 단백질의 Ser77 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능. 세포 증식 및 분화 관련 연구에 적합. 인간 및 생쥐 시료 반응성. -20°C에서 1년 보관.
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SRF (phospho Ser77) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SRF (phospho Ser77) rabbit pAb |
| Alternative Names | SRF; Serum response factor; SRF |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SRF around the phosphorylation site of Ser77 (AA range: 41–90) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 52 kD |
| Gene ID (Human) | 6722 |
| Human Swiss-Prot No. | P11831 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. It regulates the activity of many immediate-early genes, such as c-fos, and participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. The gene acts downstream of several signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway through ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been identified (RefSeq, May 2014).
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